The Genomics and Microarray Core at the University of Colorado Denver is a genomic and proteomic facility providing access to Next Generation Sequencing, DNA microarray, single-cell genomics, and Somalogic proteomic technology for the University and surrounding research institutions. We also assist with experimental design consultations and data analysis. An integral part of the core is the formal relationship with the University Bioinformatics Core to offer customers data analysis using novel algorithms.



The services offered by the core facility are listed in the following Table.

ServicesTechnologies/PlatformsApplications
DNA Next-Gen SequencingIllumina HiSeq 4000DNA de novo or Resequencing, Gene Expression Profiling, Transcriptome Analysis, SNP Discovery and Structural Variation, DNA-Protein Interaction Analysis, Methylation Analysis, Small RNA Discovery, Cytogenetic Analysis, Validation of Profiles, Targeted Resequencing
Illumina HiSeq 2500
Illumina MiSeq
LifeTech IonPGM
DNA Microarray AnalysisAffymetrix GeneChip SystemDNA Resequencing, Gene Expression Profiling, Transcriptome Analysis, SNP Discovery and Structural Variation, DNA-Protein Interaction Analysis, Methylation Analysis, Small RNA Discovery, Cytogenetic Analysis
Affymetrix GeneTitan System
Illumina iScan System
Agilent SureScan Microarray System
Single-Cell GenomicsFluidigm C1, Juno, Access Array and Biomark HD SystemsAll Genetic and Genomic Analysis at Single Cell Level
ProteomicsSomalogic SOMAScanAptamer-based Protein Profiling of 1310 Human Proteins, Protein Biomarker Discovery and Diagnosis
DNA/RNA Quantity and Quality AnalysisNanodrop ND-1000 UV/VisSample quality control within any Next Generation Sequencing , microarray or quantitative PCR workflow
Agilent 2100 Bioanalyzer and 2200 Tape Station
Qubit Fluorometer
Tecan Infinite M200pro
Bio-Rad CFX96 Real-time PCR
DNA/RNA ShearingCovaris S220 Focused-ultrasonicatorDNA, RNA, and chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization.
Pre-Experimental Design, Technology and Data Analysis ConsultationAffymetrix, Agilent and Illumina Array SoftwareExperimental Design Consultation, Gene Annotation, Clustering Analysis, Pathway Analysis, Comparative Analysis, Gene Ontology analysis, Classification Analysis, Promoter Analysis, Time Course Data Analysis, Protein Domain Analysis, Public Repository Submission, Customized Data Analysis, Data Analysis Training
Illumina and IonPGM Sequencing Control Software and Pipeline Software CASAVA
Commercial Partek Genomics Suite, GeneSpring GX, and Ingenuity IPA
Online Public Resources, including R, and Bioconductor